Characterization and time course of pulmonary lesions in calves after intratracheal infection with Pasteurella multocida A:3.

نویسندگان

  • M P Dagleish
  • J Finlayson
  • C Bayne
  • S MacDonald
  • J Sales
  • J C Hodgson
چکیده

Pasteurella multocida A:3 is a common cause of suppurative bronchopneumonia in calves and results in significant production losses and mortality. Here we describe the lesions in three calves at each of four time points (1 day and 4, 7 and 10 days) after experimental intratracheal infection with approximately 1x10(9) colony-forming units of P. multocida A:3 Moredun Research Institute (MRI isolate 671/90). Equivalent age- and time-matched sham-dosed negative control animals were also studied. Infected calves developed significantly elevated mean rectal temperatures (P<0.001) and respiratory rates (P<0.001) compared with negative control animals. Extensive consolidation of multiple lung lobes was present on each of the day/s post-infection (dpi). Histologically, large numbers of alveoli contained either or both polymorphonuclear neutrophils (PMNs) and oedema fluid (1 dpi). At 4 dpi a severe fibrinosuppurative bronchopneumonia had developed. At this time, PMNs and macrophages formed focal lesions containing central necrotic and mineralized debris, while the interlobular septa were severely distended by oedema. Early abscess formation was present in the lung parenchyma at 7 dpi and many of the interlobular septa were thrombosed. At 10 dpi abscesses within the lung parenchyma were mature and comprised of central necrosis with surrounding layers of PMN, macrophages and fibrous tissue. This study describes, for the first time, the commencement, nature and progression of lesions in bovine pneumonic pasteurellosis caused by P. multocida A:3 and provides the foundations for further investigation of the pathogenesis of this disease in cattle.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Pathological Changes in the Lungs of Calves Following Intratracheal Exposure to Pasteurella multocida B:2

Pasteurella multocida B:2 is an etiological agent of hemorrhagic septicemia in cattle and buffaloes. It is commonly fatal and considered as one of the most economically important cattle diseases in Southeast Asia. This study describes the pathological changes in the lungs of calves following intra-tracheal challenge with wild-type P. multocida B:2. For this purpose, six calves of 8-month old we...

متن کامل

Bacteriological and therapeutic studies on Mannheimia haemolytica and Pasteurella multocida in bovine respiratory disease at dairy cattle farms in Tehran

In this study, we performed a bacteriological investigation on bovine respiratory infections. Additionally, the study evaluates the efficacy of florfenicol 30 µg produced by Rooyan Darou Company (test group) as compared to a similar drug produced by Aboraihan Company (control group). Sampling was carried out on 30 calves at two farms with 30-55% incidence rate of respiratory disorders. Nasophar...

متن کامل

Antimicrobial susceptibility testing of Mannheimia haemolytica and Pasteurella multocida isolated from calves with dairy calf pneumonia

  This study evaluated the nasopharyngeal microbial flora and antimicrobial susceptibility patterns of the one hundred and thirty Holstein calves with dairy calf pneumonia from dairy farms of Mashhad Suburb between September 2002 and August 2003 . The most common micro-organisms isolated were Pasteurella multocida 80 (61.54%), Mannheimia haemolytica 41 (31.54%), Bacillus sp. 15 (11.54%), Staphy...

متن کامل

Methods of Preparation of Live Attenuated Bacterial Vaccine by Alteration of Dna Adenine Methylase (dam) Activity in Those Bacteria

U.S. Appl. No. 10/767,441, filed Jan. 30, 2004, Pending. U.S. Appl. No. 11/372,187, filed Mar. 10, 2006, Pending. Carter, "Observations on the Pathology and Bacteriology of Shipping Fever in Canada", Can. J. Comp. Med., vol. 18, No. 10, pp. 359-364, 1954. Collier, "Significance of Bacteria in Bovine Respiratory Disease", A.V.M.A., vol. 153, No. 12, pp. 1645-1651, 1968. Schiefer, et al., "Correl...

متن کامل

Molecular detection and pathology of Pasteurella multocida B:2 in the reproductive system of pre-pubertal buffalo calves (Bubalus bubalis) ABSTRACT Pasteurella multocida is responsible for one of the major animal diseases

Pasteurella multocida is responsible for one of the major animal diseases with economic importance in both developed and developing countries. P. multocida B:2 causes haemorrhagic septicemia (HS) in cattle and buffaloes, which result in heavy economic losses through direct effect, resulting in high mortality rates and indirect effects through impairment of the animal productivity. It is well kn...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of comparative pathology

دوره 142 2-3  شماره 

صفحات  -

تاریخ انتشار 2010